Publications

2020

A Thalamic Orphan Receptor Drives Variability in Short Term Memory.

Hsiao K, Noble C, Pitman W, Yadav N, Kumar S, Keele GR, Terceros A, Kanke M,  Conniff T, Cheleuitte-Nieves C, Tolwani R,  Sethupathy P, Rajasethupathy P.

Cell 2020 (Link) (PDF)

Nature News & Views

Proceedings of the Seventh Annual Deep Brain Stimulation Think Tank: Advances in Neurophysiology, Adaptive DBS, Virtual Reality, Neuroethics and Technology. 

Ramirez-Zamora A, Giordano J, Gunduz A, Alcantara J, Cagle JN, Cernera S, Difuntorum P, Eisinger RS, Gomez J, Long S, Parks B, Wong JK, Chiu S, Patel B, Grill WM, Walker HC, Little SJ, Gilron R, Tinkhauser G, Thevathasan W, Sinclair NC, Lozano AM, Foltynie T, Fasano A, Sheth SA, Scangos K, Sanger TD, Miller J, Brumback AC, Rajasethupathy P, McIntyre C, Schlachter L, Suthana N, Kubu C, Sankary LR, Herrera-Ferrá K, Goetz S, Cheeran B, Steinke GK, Hess C, Almeida L, Deeb W, Foote KD, Okun MS.

Front Hum Neurosci. 2020  (Link) (PDF)

2016

Roles for small noncoding RNAs in silencing of retrotransposons in the mammalian brain.

Nandi S, Chandramohan D, Fioriti L, Melnick AM, Hébert JM, Mason CE, Rajasethupathy P, Kandel ER. 

Proc Natl Acad Sci U S A. 2016  (Link) (PDF)

Targeting Neural Circuits. 

Rajasethupathy P, Ferenczi E, Deisseroth K. 

Cell. 2016  Review  (Link) (PDF)

Multiplexed Intact-Tissue Transcriptional Analysis at Cellular Resolution. 

Sylwestrak EL, Rajasethupathy P, Wright MA, Jaffe A, Deisseroth K. 

Cell. 2016  (Link) (PDF)

2015

Projections from neocortex mediate top-down control of memory retrieval. 

Rajasethupathy P, Sankaran S, Marshel JH, Kim CK, Ferenczi E, Lee SY, Berndt A, Ramakrishnan C, Jaffe A, Lo M, Liston C, Deisseroth K. 

Nature. 2015  (Link) (PDF)

MicroRNA-22 Gates Long-Term Heterosynaptic Plasticity in Aplysia through Presynaptic Regulation of CPEB and Downstream Targets. 

Fiumara F, Rajasethupathy P, Antonov I, Kosmidis S, Sossin WS, Kandel ER. 

Cell Rep. 2015  (Link) (PDF)

2013

New mechanisms in memory storage: piRNAs and epigenetics. 

Landry CD, Kandel ER, Rajasethupathy P. 

Trends Neurosci. 2013 Review. (Link) (PDF)

A strategy to capture and characterize the synaptic transcriptome. 

Puthanveettil SV, Antonov I, Kalachikov S, Rajasethupathy P, Choi YB, Kohn AB, Citarella M, Yu F, Karl KA, Kinet M, Morozova I, Russo JJ, Ju J, Moroz LL, Kandel ER. 

Proc Natl Acad Sci U S A. 2013  (Link) (PDF)

2012

A role for neuronal piRNAs in the epigenetic control of memory-related synaptic plasticity.

Rajasethupathy P, Antonov I, Sheridan R, Frey S, Sander C, Tuschl T, Kandel ER.

Cell. 2012  (Link) (PDF)

2009

Characterization of small RNAs in Aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB. 

Rajasethupathy P, Fiumara F, Sheridan R, Betel D, Puthanveettil SV, Russo JJ, Sander C, Tuschl T, Kandel E. 

Neuron. 2009  (Link(PDF)

2005

Systems modeling: a pathway to drug discovery. 

Rajasethupathy P, Vayttaden SJ, Bhalla US.

Curr Opin Chem Biol. 2005 Review.   (Link) (PDF)

2004

Selection of stable RNA molecules that can regulate the channel-opening equilibrium of the membrane-bound gamma-aminobutyric acid receptor. 

Cui Y, Rajasethupathy P, Hess GP.

Biochemistry. 2004  (Link) (PDF)

Patents

2017

RNA Fixation and Detection in CLARITY-based Hydrogel Tissue US20190119735A1 (Pending)

Methods, kits, and systems for fixation of RNA permitting its detection in intact tissue, such as, large volume of mammalian tissue are disclosed. The methods, kits, and systems utilize carbodiimide-based chemistry to stably retain RNAs in tissue clarified using CLARITY. Also provided herein are methods, kits, and systems for detection of RNAs in clarified tissue.

​Karl A. Deisseroth, Emily L. Sywlestrak, Priya Rajasethupathy, Matthew Wright (2017) (Link) (PDF)